Large heavy lift airships have broad application prospects. However, the design and analysis technology of advanced composite framework structure with large size and span in space has been one of the key technologies restricting the development of large heavy lift airships. Therefore, conducting research on this has important practical engineering significance. This paper takes a certain heavy lift airship framework as the research object, takes the relevant requirements given by the overall design as the design input conditions, selects the more mature material system and structural connection form, and completes the design of the airship composite framework structure. The main structural element of the framework is a triangular truss beam, and a parametric modeling method based on Python language is developed for the framework structure of the airship. Based on the principle of stiffness equivalence, the method transforms the triangular truss into a spatial beam element, automatically generates the overall finite element model of the framework and defines the connection relationship, which realizes the parametric and rapid modeling of the framework structure of the airship. The overall stress and deformation calculation of the framework was carried out for the typical loading condition of hovering loading and unloading of airships, and the "global-local" method was applied to reduce the equivalent beam element, which has severe stress loads in the overall finite element analysis, into a refined triangular truss model. Based on the Hashin failure criterion, the strength calculation and calibration of composite circular tubes, joints and other structural elements were carried out, and the results verified the validity of the method. The method can be used to guide the design and mechanical analysis of large size complex span truss structures, including large heavy lift airship framework for raising the efficiency of calculation.