In order to guarantee the model switching stability of uncertain tilt-rotor aircraft from the helicopter mode to the fixed-wing mode， a fuzzy adaptive switching control strategy is proposed based on the model-dependent average residence dwell time method. Firstly， the longitudinal motion system model of tilt-rotor aircraft is established. Secondly， the fuzzy logic system is constructed to approximate and handle the unknown uncertainty in the mode transition process of tilt-rotor aircraft. The fuzzy adaptive robust flight control strategy is presented to ensure the smooth switching of tilt-rotor aircraft， and the effectiveness of the proposed controller is strictly proved via the theoretical analysis. Finally， the simulation results show that the proposed control method can effectively realize the trajectory tracking in the mode transition process of tilt-rotor aircraft， and improve the maneuverability and stability of the aircraft.