In order to accurately estimate the impact of the fluid-structure coupling effect on the vibration response and noise calculation of rotor blades， a computational fluid dynamics （CFD） model and a high-precision structural finite element model are established in this paper. One-way and two-way fluid-structure coupling calculations are completed based on the weak coupling method， and the Kirchhoff method is adopted to solve the FW-H equation so as to analyze the rotation noise of the rotor blade. Firstly， a finite element model with high precision is established based on a modal test， and the CFD calculation is completed. Then， the numerical results of CFD are transferred to structure by using two grid mapping methods and a quaternion interpolation approach so that one-way static and transient fluid-structure coupling analysis can be acquired. Secondly， the structure’s dynamic response and transient flow field are calculated by using the weak coupling method， so we can analyze the difference between the one-way and two-way solution. Finally， the rotation noise of the blade is calculated based on the time-varying aerodynamic pressure， which results from the one-way and two-way fluid-structure calculation. And the magnitude and distribution characteristics of rotation noise calculated by one-way and two-way fluid-structure methods are analyzed and compared. The results show that the dynamic response and noise propagation of the rotor calculated based on the high-precision model and two-way fluid-structure coupling method accord with the law of hovering rotation noise， which can provide reference for blade design， strength check， and noise prediction in the future.