A nanosecond pulse laser is used to conduct laser cleaning experiments on the oxide after welding of 6061 aluminum alloy. Firstly， This paper analyzes the surface morphology and elemental composition of the solder joint before and after cleaning， and determines the composition of the oxide after welding. Secondly， based on the influence of different process parameters on cleaning quality obtained from previous experiments， orthogonal experiments are designed to delineate the range of each factor interval and analyze the weight of the influence of parameters on cleaning quality.By using the orthogonal experimental method， it is found that the order of parameters affecting the peak valley values of surface contour lines is： Laser power>pulse frequency>scanning speed>pulse width. The order of parameters that affect the weight percentage of o element is： Pulse width>scanning speed>laser power>pulse frequency. The optimal process parameter group is obtained through the comprehensive balance method： Scanning speed， laser power， pulse frequency， and pulse width are 2 950 mm/s， 141 W， 29 kHz， and 330 ns， respectively. The optimal parameters can ensure thorough oxide cleaning， no substrate damage， and high cleaning efficiency of aluminum alloy after welding.