To investigate the influence of design parameters of anti-icing chamber of hot air anti-icing systems of piccolo tube on heat transfer characteristics of inlet lip skin， coupled simulation of internal and external flow of anti-icing chamber and solid domain under different parameters are conducted. The impact of different design parameters such as hole diameter， vertical distance between holes and lip skin on temperature， convection heat transfer coefficient and Nusselt （Nu） number distribution of inlet lip skin lower surface are obtained. The results show that while the values of hole diameter and vertical distance between holes and lip skin are within a certain range， the temperature of inlet lip skin and convection heat transfer coefficient increase with the increase of jet hole diameter and with the decrease of distance between middle row holes and lip skin.