The piccolo tube is an important part of the aircraft hot air anti-icing system. The diameter and spacing of the holes on piccolo tube and the inlet pressure of hot air determine the amount and distribution of the supplied anti-icing hot air， thus affecting the anti-icing performance. Based on the multi-disciplinary system modeling and simulation platform AMESim， the flow distribution simulation model of piccolo tube is established， and the structural parameters of piccolo tube of wing hot air anti-icing system are iteratively designed. The design parameters include diameters of piccolo tube， orifice diameter and spacing. After several iterations， the values of structural parameters and bleed air flow distribution that can balance the anti-icing thermal load at the design state point are obtained. Furthermore， the pressure schedule of bleed air for the anti-icing system is determined. The proposed iterative design method of piccolo tube based on AMESim can provide reference for the design and optimization of piccolo tube in hot air anti-icing system.