By analysing the aircraft forces under the effect of crosswind， the theoretical model of tire-pavement interaction is introduced to obtain the main influencing factors in crosswind and ABAQUS is used to establish the interaction model between the cornering tire and the runway pavement. The effect of the slip angle and different runway water thicknesses on the interaction between aircraft tires and the pavement surface is studied. The results indicate that the crosswind causes the aircraft to deviate from the runway center line when the aircraft taxis， and the slide force of the tire on the runway pavement is an important factor affecting the distance of the aircraft’s center of mass from the runway center line. An increase in tire slip angle leads to an increase in tire grounding characteristics and a progressive increase in the length of water front area. The distribution of water front pressure increases asymmetrically， in which the high pressure area is concentrated on the side of tire deflection and the maximum value is close to 1 MPa. At this time， there is a risk of water skiing. With the increase of the thickness of water， the lateral friction coefficient of the wet pavement decreases. When the thickness of water reaches the critical value of 13 mm in the airport operational regulations， the lateral friction coefficient of the wet pavement is only half of that of the dry pavement， which greatly increases the risk of aircraft deviating from the runway.