In order to develop a centrifugal fuel booster pump that can meet the requirements of a helicopter fuel supply system, a simulation model of the fuel supply system is created on the Matlab/Simulink simulation platform, and the fuel supply system is simulated and analyzed systematically. The pressure boost value of the centrifugal pump is given. The ground simulation test of the fuel supply system is carried out and compared with the simulation calculation. The result shows that the simulation calculation relative error is 2.8% compared with the engine fuel shut off test, and the maximum relative error of the simulation calculation is 7.2% compared with the normal fuel supply test results of the engine. These results indicate that the simulation model has high accuracy, and the determined centrifugal pump pressure boost values can meet the requirements of the helicopter for the fuel supply system.