This article aims at the communication system of civil airliner. This research takes the cost as the constraint condition and weighs the system safety and reliability. First， the reliability and safety index of the communication system is determined， and extracted by the gray correlation analysis and the multiple linear regression. The key impact factors are quantified， and MATLAB software is used to establish a single-object-multi-objective integrated weighted index ZETA scoring model. According to the actual requirements， the different trade-off domains in the optimization results are compared and analyzed. Finally， according to the development cost of the civil aircraft communication system， The kernel and gray Markov prediction model predicts and calculates the average error of the future R&D cost of a certain series of civil airliner communication systems， and verifies the feasibility and credibility of the integrated optimization model. The results demonstrate that the integrated trade-off model is useful and can be reference for engineering practice.