Morphing aircraft could change its shape to adapt to the different flight conditions and improve the flight performance. Morphing aircraft design involves aerodynamics， materials， structure and other disciplines. With zero Poisson’s ratio honeycomb structure material as the flexible skin， a seamless deflection trailing edge of wing is designed. The reference area of the wing does not decrease due to changes in camber. And the multidisciplinary design optimization of the morphing wing trailing edge is studied. The optimization results show that the optimized wing provides good aerodynamic performances under cruise and takeoff and landing conditions. The flexible skin can produce a large-scale tensile deformation， the trailing edge structure of wing meets the stiffness， strength and other performance requirements， and the weight of the wing structure is reduced by 18% compared with the initial design. The studied multidisciplinary design and optimization method of morphing wing can quickly and effectively complete the seamless deflection trailing edge of wing design and optimization.