In the process of ejection take-off， shipboard aircraft are subject to large load， large acceleration， short distance and short time， as well as the influence of atmospheric disturbance and shipboard movement. There is a complex strong nonlinear multidisciplinary dynamics coupled problem. A simple multi-body dynamic model of shipboard aircraft-ejection system is established. Under the action of ship surface shaking load and cross wind load， ADAMS is used to conduct rigid-flexible coupled multi-body dynamic simulation analysis of shipboard airframe ejection take-off， and the overload transfer path and strain distribution of airframe during ejection take-off are obtained. Through the comparison between the simulation analysis and the experimental data in the related literature， it is shown that this simulation method can effectively simulate the ejection take-off process of shipboard aircraft under the strong nonlinear and complex load coupling， providing reference for the whole process research of shipboard aircraft ejection take-off and the design of fuselage structure.