Pultruded rod stiffened efficient unitized structure (PRSEUS) can meet structure design requirements of load transmission, damage arresting, stability and maintainability in hybrid wing body (HWB) civil aircraft by combining composite material integrated stitching and co-cure technique. Comparing with existing composite material manufacturing technique, the manufacturing of PRSEUS panel uses integral structure design method at low cost to complete the process of fiber knit, stitching and resin infusion by applying knit machine, one side stitching and controlled atmospheric pressure resin infusion technique. Moreover, the additional out of surface strength is enhanced by co-cure at low temperature and stitching technique. The diverse design requirements of different position structure panel design in HWB structure are satisfied easily by reasonable material selecting and process design. In this paper, latest developments and current techniques of HWB civil aircraft PRSEUS panel manufacturing technology are presented from aspects of HWB civil aircraft PRSEUS structure material selecting design, PRSEUS structure manufacturing core process, PRSEUS structure fixture and clamp, representative PRSEUS test panel manufacturing and representative fuselage article manufacturing. Thus, by summary and prospect on research progress of PRSEUS structure manufacturing technique, the research here provides valuable technical reference and research direction for design and manufacturing of civil aircraft structure and development on novel material structure of our country in the future.