In order to improve the operational efficiency and operation benefits of large manned space infrastructure represented by space stations, this paper investigates the International Space Station(ISS) operation mode and commercialization practices. In view of the in-orbit operation characteristics, national strategic and social commercialization needs of China’s existing space infrastructure, suggestions on introducing social capital to establish commercial operation model and achievement transformation fund are raised. It is required to build a specialized commercial operation management organization for overall management and commercial operation and to establish a set of commercial operation management system with definitive responsibility, high quality and efficiency, and outstanding benefits, which will not only ensure the healthy operation of space infrastructure in orbit and various of space applications efficiently developed, but also reduce the construction and operation costs. With its practical significance and social benefits, the paper would help cultivate business models and innovative projects so as to promote economic and social development.