The seperate construction of measurement and control system, operation control system and application system of satellite project can bring about problems such as manage fragmentation, inconsistent system architecture and frequent artificial communication among systems. This paper introduces the integrative construction of the satellite ground system mission center. The integrative cloud computing system architecture, flattened two-layer network architecture, platform and plug-in software architecture and integrative workflow are introduced. The key technology in building reliability and adjustability of basic platform in the mission center is described. By the uniform technology architecture, the common computing and storage devices are scheduled as a whole resources, the various data and products are shared and managed, and the entire task flow and devices’ status in the mission center are monitored. The integrative mission center achieves the designed purpose. The platform is steady and reliable, the operation is automatic and highly efficient, and the image products are legible and exact. The measurement and control system, operation control system, application system and stations management system are uniformly managed and operated together in the mission center.