Aiming at the fact that the existing location model only considers the shortage of logistics cost, the concept of reliability is introduced to the location of the spare parts support center, and a multi-objective location model based on reliability is proposed. Firstly, the concept and quantification method of the reliability of the spare parts support center system is given in combination with the definition of reliability. Secondly, the multi-objective location model with the shortest total transportation path, the lowest total cost and the highest reliability of the spare parts support center system are constructed under the premise of satisfying the random needs of users. Thirdly, a greedy heuristic algorithm is designed based on the principle of high priority of user reliability. Finally, the simulation verifies that the proposed model provids theoretical support for the locations of spare parts support center.