Air distribution and thermal comfort of human body in a civil aircraft cabin are affected by many factors, such as ventilation air temperature, air distribution system and air flow, etc. In these factors, the air distribution mode is largely limited by the interior aesthetics design results in model civil aircraft design. It is very necessary to optimize the air distribution mode for the civil aircraft. This paper adopts a new CFD fluid simulation technology, which is combined with cabin aesthetics design, to carry the thermal comfort design study for civil aircraft cabin. A multi-objective optimization method is used to automatically realize the CFD optimization design for the air distribution mode. The optimal outlet position of air distribution mode can be obtained. The optimization results can improve the air distribution performance and cabin thermal comfort around passengers. In addition, study results also show that the Coanda effect will change the flow path of the air supply and affect the utilization rate of fresh air and the comfort of passengers.