For the safe reentry flight of hypersonic vehicle under faults, considering the existence of various uncertain parameters and torque faults in the control system, we propose the integrated design of the hypersonic vehicle reentry adaptive fault-tolerance guidance and control. First, owing to the design of separate channel integrated guidance and control(SCIGC) cannot coordinate the fault-tolerance of the guidance and control system simultaneously, the coupling relationship between the guidance and the attitude is considered, and an integrated and coupling model of guidance and control is established. Then, for the integrated coupling model, an adaptive fault-tolerance integrated guidance and control (IGC) is designed. An adaptive dual-loop sliding mode fault-tolerance controller is designed, and a Takagi-Sugeno(TS) fuzzy model is used to approach the complex disturbances caused by unknown parameters and additive faults. Finally, the adaptive parameters in the controller are designed based on the Lyapunov stability theorem. At the same time, the projection operator is introduced to ensure the bound of the parameters, and the design parameter adaptation law is used to update the fault-tolerance controller online, so as to complete the design of the integrated program of adaptive fault-tolerance guidance and control. Under the fault conditions, the effectiveness of the adaptive fault-tolerant IGC is verified through the simulation comparison between IGC and SCIGC.