The fretting wear characteristics of TC21 alloy are studied by using the FTM wear testing machine at the elevated temperature of 150 ℃. The influence of temperature on friction coefficient and wear ratio is analyzed. Moreover, the changes of morphology and chemical elements on wear scar and the wear mechanism of TC21 alloy are discussed by the means of scanning electron microscope, energy dispersive spectrometer. The results show that the influence of temperature on the friction coefficient of TC21 alloy is affected by the displacement. The displacement is small and the temperature has little effect on the friction coefficient of TC21 alloy. Compared with the room temperature, the wear rate is decreased 67.4%—86.5% at 150 ℃.The primary wear mechanism of TC21 alloy is mainly abrasive wear, along with oxidation wear and adhesive wear at the room temperature, and that is oxidation wear at the temperatures of 150 ℃, along with a little abrasive wear and adhesive wear．