An efficient meshing strategy is developed to generate a high quality point-to-point multi-block structured grid for a grid fin missile, and the N-S equations are solved numerically using the finite volume method on the herein generated multi-block structured grid. With these strategies the hypersonic flow around a grid fin missile is simulated, and three different grid fin airfoil shapes are adopted to analyze the aerodynamic force and aerodynamic heating. The calculation results show that plat airfoil shape grid fin is the worst for the characteristics of aerodynamic force and aerodynamic heating. The arc airfoil shape(R=1 mm) grid fin is the best for the characteristics of aerodynamic heating, and the wedge-arc airfoil shape(R=0.5mm) has the smallest drag.