For the performance testing of cabin pressure control system (CPCS), a high-altitude simulation cabin (HASC) system based on the virtual instrument is established to simulate the atmospheric pressure which varies with aircraft flight states. On the basis of SCXI virtual instrument platform, a digital proportion-integration-differentation (PID) controller is developed in Labview to accomplish the HASC pressure control. The performance test of digital-pneumatic cabin pressure controlling system is carried out with the HASC system. The results show that the HASC system can accurately simulate the atmospheric pressure of flight states which is very important in CPCS performance testing.