The driving efficiency of the cable network transmission for morphing trailing-edge depends largely on spatial arrangement of each cable. Firstly, the mechanical model of the cable network transmission is developed. The differential iterative scheme is given for the nonlinear differential equations of the cable network and mid-plate. Secondly, the explicit function of driving force and the minimum distance between cable and skin is introduced by use of the response surface methodology. Lastly, the optimization problem is solved by the sequential quadratic programming algorithm. The results show that the response surface models of driving force and the minimum distance between cable and skin have high accuracy. The driving force is reduced by 27.7% in the optimized cable network.