Based on civil aircraft nacelle anti-ice architecture and certification regulation requirement， engineering simulation process and efficiency improvement solution for performance analysis are depicted. Criteria for nacelle anti-ice performance and common analysis cases are summarized as simulation requirement. The energy balance and mass balance are analyzed for the external flow field， the inner flow field and the thermal-coupling skin. The simplified requirements and methods of engineering are proposed for the computational mesh. An inverse distance-weighted interpolation algorithm based on K-nearest neighbor search is innovatively adopted. This method can greatly improve the solution efficiency compared with the traditional exhaustive method interpolation， and has the characteristics of grid independence. Compared with the classic surface layer integration method to solve the convective heat transfer coefficient， this simulation model adopts the convective heat transfer coefficient correction empirical formula of the swept round pipe after comprehensively considering the three-dimensional effect and the solution efficiency， and provides an interface for subsequent model correction. Based on the self-built anti-icing performance analysis model of civil aircraft， this study carries out the anti-ice analysis of the existing nacelle type. The comparison between the calculation results and the surface temperature of flight test data shows that the optimization in this simulation meets the needs of engineering analysis and greatly improves the solution efficiency.