To meet the requirements of the large aperture and high precision of space-borne carbon fiber honeycomb sandwich reflectors, a manufacturing method based on design, process and measurement is presented. In this method, the shape accuracy of the reflector is improved by means of a high thermal stability and high precision mould, the residual stress during curing is reduced by a honeycomb splicing method, the residual stress of the reflector parts after curing is reduced by a high and low temperature aging method, and the measurement accuracy of the reflector is improved by optimizing the measuring method. The result shows that the manufacturing accuracy and the thermal deformation of the reflector can be improved effectively by the manufacture technology.