A multi?scale analysis method for aircraft structure was established to analyze the mechanical behavior of aircraft structures, determine the dangerous area and study the damage mode efficiently and accurately. Three finite element models, namely, the overall structure finite element model, the local structure finite element model and the single-nail connection finite element model, were established to analyze the structure of aircraft by using the hierarchical multi?scale method. The information transmission and feedback between the macro variables and the mesoscopic response were established. The macroscopic stiffness and strength properties of the three?direction orthogonal carbon/carbon woven composites were predicted, and the macroscopic damage initiation envelope was established. The progressive damage analysis of the single-nail connection model was carried out by the synergistic multi-scale method. It is shown that the method has good applicability and can accurately analyze the damage mode of the structure. The presented research may provide a reference for design of aircraft structures.