Reliability, economy and environmental protection are the operational requirements of civil aircraft design. Through the systematic study on the influence factors of dispatch reliability, total life cycle cost and carbon emission model, the total life cycle cost,carbon emission model and dispatch reliability are constituted into multi-objective optimization function. Meanwhile, according to the performance requirements of the actual operation, the constraint equation is established and multi-objective optimization model is established. Then, the genetic algorithm is used to achieve the intelligent optimization calculation of the optimization model.Taking A320 typical data as an example, optimal calculation is carried out for different design objectives. Results show that the optimization method is feasible, and it can provide reference for the selection of the aircraft conceptual design parameters.