Based on the analysis of the principle of GPS deception jamming, the control characteristics of unmanned aerial vehicle (UAV) GPS/INS integrated navigation system are considered and the innovative detection rule of state estimation in UAV navigation system is designed. Methods of direct trajectory cheating and trajectory fusion are adopted to achieve the UAV navigation system intrusion control and realize the purpose of UAV flight path control with the GPS deception jamming. In this paper, the normalized innovation squared is given through theoretical derivation and simulation analysis. The results show that when the control method of trajectory fusion is adopted, not only the trajectory deception can be realized, but also it is difficult to be detected, which provides an effective means of interference for GPS confrontation.