The compressive bearing behavior， failure mode and failure mechanism of sandwich panels composed of different composite panels and Nomex honeycomb are discussed through low-velocity impact and compression after impact tests. The failure modes of the specimen are obtained by non-destructive C-scan tests， Micro-CT and DIC digital measurements. The results show that the material damage modes mainly include panel fiber fracture， matrix and fiber interface debonding， matrix cracking， shear failure and crushing of core material. Compared with the carbon fiber composite sandwich structure， the carbon/aramid hybrid composite sandwich structure has better interlaminar properties. Furthermore， the interlayer hybrid structure has higher compressive stiffness and residual compressive strength than the intralayer one.