In order to apply rich/quenching/Lean (RQL) combustion technology to the design of high temperature rise combustor, the design of quenching zone was optimized to achieve the best mixing performance. The numerical simulation method was used to study the mixing performance with different pressure loss, jet to mainstream flow ratio, quenching hole and swirler structure under normal temperature and atmospheric pressure. The results show that the best spacing between the quenched holes makes the mixing performance best in the quenching zone. The mixing performance in the quenching zone decreases with the axial displacement of the quenching hole. The mixing performance in the quenching zone increases with the increase of the flow ratio between the jet and the main flow, but there is a critical value. Increasing the diameter of quenching hole is beneficial to the enhancement of mixing performance in quenching zone under the same flow rate condition. The increase of turbulence intensity could promote the quick mixing of airflow in quenching zone. When the quenching holes are located in H/2, the quenching zone has a good mixing performance by using the staggered arrangement and symmetrical arrangement of three holes. In addition, the increase of the number of quenching holes and the decrease of the area of single hole are not conducive to the quick mixing of the airflow in the quenching zone.