In order to study the influence of panel thickness, different types and degrees of congenital defects on the fatigue performance of aluminum honeycomb sandwich panel, three point bending static load test and three point bending fatigue test were carried out on seven groups of aluminum honeycomb sandwich panel samples.The results show that the surface core dewelding defects have the greatest influence on the fatigue performance of aluminum honeycomb panel, and the fatigue performance of the specimens containing 10% and 30% surface core dewelding defects decreases by 76% and 92%, respectively, indicating that it is very important to prevent the surface core dewelding defects.Through analysis, the bending fatigue characteristics of aluminum honeycomb panel obey Weibull distribution, and the correlation coefficient exceeds 0.95.Weibull equations reflecting the relationship between stress level and fatigue performance were established for intact samples and samples with different types and degrees of congenital defects.